Histamine: Substance that plays a major role in many allergic reactions. Histamine dilates blood vessels and makes the vessel walls abnormally permeable.
DOSING: Hydroxyzine has its maximal effect about 30 to 60 minutes after it is taken. Its effects last for 4 to 6 hours. The recommended dose for treating pruritus is 25 mg given 3 or 4 times daily. When used for sedation, the recommended dose is 50 to 100 mg. Anxiety and tension are managed with 50 to 100 mg 4 times daily. Hydroxyzine can be taken with or without food.
Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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