Desloratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Desloratadine does not readily enter the brain from the blood and, therefore, causes less drowsiness (sedation). It is a member of a small family of non-sedating antihistamines which includes loratadine (Claritin), cetirizine (Zyrtec), and azelastine (Astelin). Desloratadine was approved by the FDA in December, 2001.
Prior to the approval of Clarinex in the United States, numerous clinical studies were conducted in over 4,000 adults and children. This included studies looking at the effects of Clarinex on seasonal allergy symptoms, perennial allergy symptoms, and chronic urticaria. In these studies, people taking the drug had improved relief, compared to the group of people not taking the medicine.
Clarinex helps relieve seasonal and indoor allergy symptoms, as well as chronic hives and itching. It works by blocking histamine -- a chemical in the body that causes sneezing, itching, and irritation when you come into contact with something you're allergic to. Clarinex does not, however, help clear nasal passages. Common side effects, while rare, include nausea, sore throat, and dry mouth.
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