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Cyproheptadine passes into breast milk. Infants are especially sensitive to the effects of antihistamines, and serious side effects could occur in a nursing baby. Cyproheptadine is not recommended if you are breast-feeding a baby. Do not take cyproheptadine without first talking to your doctor if you are nursing a baby.

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An underweight individual may use periactin to stimulate his appetite in order to gain weight. This usage of the drug in this way has not been approved by the Food and Drug Administration.

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You may not be able to take cyproheptadine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

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