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Do not take cyproheptadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

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Periactin may be prescribed to an individual to relieve symptoms of the common cold. The cold symptoms it may be able to relieve are sneezing and a runny nose primarily.

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Cyproheptadine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold. Although not approved by the FDA for this purpose, cyproheptadine has been used to stimulate appetite in underweight patients.

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