Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking cyproheptadine. Do not take cyproheptadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.
If you are over 60 years of age, you may be more likely to experience side effects from cyproheptadine. You may require a lower dose of this medication.
Excess secretion of adrenocorticotropic hormone (ACTH), the hormone that stimulates the adrenal gland to produce cortisone, is associated with increased serotonin levels in the brain. Cyproheptadine has been used in the treatment of Cushing's disease, where there is excess cortisone production but not with reliable success.
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