Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Phenergan (promethazine) is now contraindicated in children younger than 2 years because of possible fatal respiratory depression and should be used cautiously in other pediatric patients, according to a new black box warning recently requested by the Food and Drug Administration. The agency requested that the black box warning be added to Phenergan's label after a review of the drug's pediatric adverse events.
Phenothiazines such as promethazine block dopamine receptors. This effect can lead to increases in blood levels of prolactin, a hormone involved in lactation (formation of breast milk). As a result, phenothiazines can cause the breast to produce fluid ("milk") even when a woman is not pregnant. Additionally, phenothiazines can cause missed menstrual periods, breast enlargement or tenderness, loss of sexual drive, impotence, inability to ejaculate, and priapism. Weight gain also may occur.
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