PREGNANCY: There are no adequate studies of promethazine in pregnant women. Administration of promethazine within 2 weeks of delivery may affect platelet function in the newborn.
Phenergan (promethazine) is now contraindicated in children younger than 2 years because of possible fatal respiratory depression and should be used cautiously in other pediatric patients, according to a new black box warning recently requested by the Food and Drug Administration. The agency requested that the black box warning be added to Phenergan's label after a review of the drug's pediatric adverse events.
Phenothiazines such as promethazine can cause skin hyperpigmentation (darkening) but usually only after prolonged use. The effect usually is restricted to areas of the body exposed to sunlight. Thus, people who need long-term treatment with promethazine should either keep out of the sun or use effective sunscreens.
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