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- There may be an increase in the risk of certain neurologic reactions that affect movement of muscles (EPS, see below) when promethazine is combined with medicines that also cause EPS. Such drugs include antipsychotics, metoclopramide (Reglan), and amoxapine (Asendin).
- USES: Promethazine is used to prevent nausea and vomiting. It is also used for sedation, allergy symptoms (runny nose, itchy eyes) and motion sickness (prevention and treatment). Use is not recommended in children less than 2 years old.
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